Dengue Virus Type 2 (DENV2)-Induced Oxidative Responses in Monocytes from Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient and G6PD Normal Subjects
Identifieur interne : 001178 ( Main/Exploration ); précédent : 001177; suivant : 001179Dengue Virus Type 2 (DENV2)-Induced Oxidative Responses in Monocytes from Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient and G6PD Normal Subjects
Auteurs : Abdullah Ahmed Al-Alimi [Malaisie] ; Syed A. Ali [Malaisie] ; Faisal Muti Al-Hassan [Malaisie] ; Fauziah Mohd Idris [Malaisie] ; Sin-Yeang Teow [Malaisie] ; Narazah Mohd Yusoff [Malaisie]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2014.
Abstract
Dengue virus is endemic in peninsular Malaysia. The clinical manifestations vary depending on the incubation period of the virus as well as the immunity of the patients. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in Malaysia where the incidence is 3.2%. It has been noted that some G6PD-deficient individuals suffer from more severe clinical presentation of dengue infection. In this study, we aim to investigate the oxidative responses of DENV2-infected monocytes from G6PD-deficient individuals.
Monocytes from G6PD-deficient individuals were infected with DENV2 and infection rate, levels of oxidative species, nitric oxide (NO), superoxide anions (O2−), and oxidative stress were determined and compared with normal controls.
Monocytes from G6PD-deficient individuals exhibited significantly higher infection rates compared to normal controls. In an effort to explain the reason for this enhanced susceptibility, we investigated the production of NO and O2− in the monocytes of individuals with G6PD deficiency compared with normal controls. We found that levels of NO and O2− were significantly lower in the DENV-infected monocytes from G6PD-deficient individuals compared with normal controls. Furthermore, the overall oxidative stress in DENV-infected monocytes from G6PD-deficient individuals was significantly higher when compared to normal controls. Correlation studies between DENV-infected cells and oxidative state of monocytes further confirmed these findings.
Altered redox state of DENV-infected monocytes from G6PD-deficient individuals appears to augment viral replication in these cells. DENV-infected G6PD-deficient individuals may contain higher viral titers, which may be significant in enhanced virus transmission. Furthermore, granulocyte dysfunction and higher viral loads in G6PD-deificient individuals may result in severe form of dengue infection.
Url:
DOI: 10.1371/journal.pntd.0002711
PubMed: 24625456
PubMed Central: 3953068
Affiliations:
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dengue Virus Type 2 (DENV2)-Induced Oxidative Responses in Monocytes from Glucose-6-Phosphate Dehydrogenase (G6PD)-Deficient and G6PD Normal Subjects</title>
<author><name sortKey="Al Alimi, Abdullah Ahmed" sort="Al Alimi, Abdullah Ahmed" uniqKey="Al Alimi A" first="Abdullah Ahmed" last="Al-Alimi">Abdullah Ahmed Al-Alimi</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Dengue virus is endemic in peninsular Malaysia. The clinical manifestations vary depending on the incubation period of the virus as well as the immunity of the patients. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in Malaysia where the incidence is 3.2%. It has been noted that some G6PD-deficient individuals suffer from more severe clinical presentation of dengue infection. In this study, we aim to investigate the oxidative responses of DENV2-infected monocytes from G6PD-deficient individuals.</p>
</sec>
<sec><title>Methodology</title>
<p>Monocytes from G6PD-deficient individuals were infected with DENV2 and infection rate, levels of oxidative species, nitric oxide (NO), superoxide anions (O<sub>2</sub>
<sup>−</sup>
), and oxidative stress were determined and compared with normal controls.</p>
</sec>
<sec><title>Principal Findings</title>
<p>Monocytes from G6PD-deficient individuals exhibited significantly higher infection rates compared to normal controls. In an effort to explain the reason for this enhanced susceptibility, we investigated the production of NO and O<sub>2</sub>
<sup>−</sup>
in the monocytes of individuals with G6PD deficiency compared with normal controls. We found that levels of NO and O<sub>2</sub>
<sup>−</sup>
were significantly lower in the DENV-infected monocytes from G6PD-deficient individuals compared with normal controls. Furthermore, the overall oxidative stress in DENV-infected monocytes from G6PD-deficient individuals was significantly higher when compared to normal controls. Correlation studies between DENV-infected cells and oxidative state of monocytes further confirmed these findings.</p>
</sec>
<sec><title>Conclusions/Significance</title>
<p>Altered redox state of DENV-infected monocytes from G6PD-deficient individuals appears to augment viral replication in these cells. DENV-infected G6PD-deficient individuals may contain higher viral titers, which may be significant in enhanced virus transmission. Furthermore, granulocyte dysfunction and higher viral loads in G6PD-deificient individuals may result in severe form of dengue infection.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>Malaisie</li>
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<tree><country name="Malaisie"><noRegion><name sortKey="Al Alimi, Abdullah Ahmed" sort="Al Alimi, Abdullah Ahmed" uniqKey="Al Alimi A" first="Abdullah Ahmed" last="Al-Alimi">Abdullah Ahmed Al-Alimi</name>
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<name sortKey="Al Hassan, Faisal Muti" sort="Al Hassan, Faisal Muti" uniqKey="Al Hassan F" first="Faisal Muti" last="Al-Hassan">Faisal Muti Al-Hassan</name>
<name sortKey="Ali, Syed A" sort="Ali, Syed A" uniqKey="Ali S" first="Syed A." last="Ali">Syed A. Ali</name>
<name sortKey="Idris, Fauziah Mohd" sort="Idris, Fauziah Mohd" uniqKey="Idris F" first="Fauziah Mohd" last="Idris">Fauziah Mohd Idris</name>
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<name sortKey="Teow, Sin Yeang" sort="Teow, Sin Yeang" uniqKey="Teow S" first="Sin-Yeang" last="Teow">Sin-Yeang Teow</name>
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